A win will see City break a Premier League record for most consecutive wins while at the same time shatter United's unbeaten record at home - which will stretch to 40 in all competitions if they avoid a loss to CSKA Moscow on Tuesday [5 December] night. To be more specific, they've flown to Kharkiv, which is where Shakhtar actually play their games nowadays due to unfortunate circumstances.
Kyle Walker, Vincent Kompany, Nicolas Otamendi, Fabian Delph, De Bruyne, Silva and Raheem Sterling did not play a single minute against Shakhtar, while Fernandinho only played 10 minutes on Sunday and Sane did not play against Southampton a week ago.
Ahead of facing Manchester United, it may be considered that City could expect Mourinho to park a bus, but at least one of Guardiola's stars is expecting the opposite at Old Trafford.
"We showed much better discipline as a team and now we need to move on".
The Serbian worldwide sat out Tuesday night's 2-1 win over CSKA Moscow which secured United's place in the UEFA Champions League knockout stages, but, speaking in his post-match press conference, the boss explained that Matic is "still injured but will play for sure".
Manchester City midfielder Yaya Toure has crowned his side the best in Europe on current form, citing their footballing style as second to none so far this season.
However, according to Sky Italia the Catalan has sent an SMS message to Napoli boss Maurizio Sarri, promising him that City will give their "maximum effort" to beat Shakhtar and make it six wins out of six in Group F.
Having already secured top spot, Wednesday's match has little riding on it for City and Guardiola is expected to rest players.
"I don't want anyone to get injured".
"They're first for good reason, because they've been doing great at the start of the season".
City's performance impressed their former defender Pablo Zabaleta, who captained West Ham on his first return to the Etihad since leaving the club in the summer. I am so pleased to see them playing that well.
"If City were to win this, are they uncatchable?"