That announcement coming via a heartfelt video message from the running back and Baton Rouge-native on Wednesday.
Guice got off to a quick start this past season, topping the 100-yard mark in each of the first two games and combining for four touchdowns.
Fittingly, LSU's No. 5 is the Tigers' fifth underclassman headed to this year's NFL Draft.
"Growing up here in Baton Rouge, it was always my dream to attend LSU", Guice said. "Having he opportunity to play for this storied university was truly an honor".
Rob Rang, a senior analyst for NFLDraftScout.com, rated Guice as a top-10 pick before his injury-plagued junior season and still has him ranked in the top 25. He had five 100-yard performances this past season, including a 276-yard effort against Ole Miss.
Guice, who shared the workload with Jaguars running back Leonard Fournette in 2016, rushed for 2,638 yards and 26 touchdowns over the past two seasons. He was then bottled up for the next stretch, failing to rush for more than 76 yards in each of the next four games.
Guice likely will be the second or third running back selected; Penn State's Saquon Barkley is considered the top back available.