A 5-0 win in their previous encounter at the Etihad will be a good source of encouragement for Pep Guardiola and he will expect his side to look beyond records and simply get the job done.
But arguably the biggest test for Liverpool will be to contain Manchester City's midfield. That formation will be mirrored by Liverpool in this clash, the side's first since Philippe Coutinho completed his move to Barcelona. The Citizens have an astounding record of 20 wins out of 22 games this season.
With the Gameweek 23 deadline set at 2pm tomorrow, Fantasy Premier League managers have a bit of time left to decide who they want to wear the armband.
Kane claimed the prize ahead of seven other nominees - Chelsea's Marcos Alonso, West Ham United's Marko Arnautovic, Liverpool duo Roberto Firmino and Mohamed Salah, Jesse Lingard of Manchester United, Leicester City's Riyad Mahrez and Manchester City's Nicolas Otamendi.
Manchester City is one of the best teams in the world and they will know that this is a game that they are expected to win.
Coutinho or not, Liverpool have a great recent record against City at Anfield, winning their last four meetings on Merseyside, and going undefeated since 2003.
The visitors have not won at Anfield since 2013 in the domestic league but will go into this game as favourites to take all three points.
City's charge gained momentum netting four goals in the next three league games against Swansea City, Spurs and Bournemouth.
While City have been irresistible at times this season, this is a strong Liverpool side - strengthened by the addition of Virgil van Dijk in defence.