It was a night to remember last time out for Liverpool, with new record signing Virgil van Dijk scoring a late victor to beat bitter rivals Everton 2-1 at Anfield and send the Reds into the next round in the FA Cup.
Manchester City won the reverse fixture 5-0 back in September - they've not done the league double against Liverpool in over 80 years, since the 1936-37 campaign that saw them win the first of their four top-flight titles.
24-year-old Kane struck eight goals - including two hat-tricks - during the last month of last year. If Aguero is on song, then City will be nigh on impossible to stop, but if van Dijk is able to keep him out of the game, the Reds will have a fantastic chance to steal victory.
Obviously there is no Philippe Coutinho after he secured his move to Barcelona this week so Sadio Mane is likely to keep his place on the opposite flank.
"I think two or three weeks", Guardiola concluded on when he expects a return for Jesus. "Against Basel in the Champions League, he could be ready".
Adam Lallana started against Everton in the FA Cup but I wouldn't be surprised to see Gini Wijnaldum get a recall on Sunday with Alex Oxlade-Chamberlain the man to provide the creativity in the middle of the park.
However, forward Gabriel Jesus and defenders Vincent Kompany and Benjamin Mendy remain out.
City could name what has become their strongest possible line-up at Anfield.
City will look to end their poor run at Anfield this weekend, with the Reds unbeaten against their rivals since 2003 on Merseyside.
Will City come unstuck at swashbuckling Liverpool?
"City's record at Anfield is poor - just one win since 1981 - but Guardiola's side are showing week by week that records are there to be broken".
"Hopefully we can do better than last season".
"What's important is what happens over 90 minutes on the field", he added.