The band will also have a concert later in the summer, August 10, at Target Field in downtown Minneapolis.
Their opening act in town will be OneRepublic.
Tickets range from $35.75 to $99.75 and go on sale at 10 a.m. Friday, Jan. 19 through LiveNation.com, Ticketmaster.com and Charge By Phone at 1-800-745-3000.
The Zac Brown Band has recorded six studio and two live albums, and is known for such chart-topping country hits as "Chicken Fried", "Toes", "Highway 20 Ride" and "As She's Walking Away" (with Alan Jackson).
With his new band, Sir Rosevelt, Zac Brown has a new song, "It Goes On", in the new Chris Hemsworth war film, "12 Strong".
The Zac Brown Band will be returning to the Lakeview Amphitheater in Syracuse this year.
The Sioux Falls performance will be unique, as it is only one of two concerts in the tour that will be performed in an arena. Sold-out stadium shows at Denver's Coors Field and Chicago's Wrigley Field anchored last year's tour.
As of now, no other shows have been announced at Alpine Valley.
"Down The Rabbit Hole Live' is a reference to the never-ending pursuit of excellence", says Zac Brown.