Loaiza was charged with possession of over 20 kilograms and two counts of transporting and possesssing narcotics with intent to sell, all felonies.
Deputies searched his rented home in Imperial Beach and said they discovered packages of white powder they believed to be cocaine.
San Diego Sheriff's Department Lt. Jason Vickery told ABC News the drugs were found in Loaiza's garage hidden in duffel bags and were packaged in a way that they appeared to have been transported from Mexico to the US for distribution throughout the country.
Esteban Loaiza, the former all-star pitcher has been sitting behind bars since his arrest last Friday and he will now face a judge this afternoon at the Chula Vista courthouse for his arraignment. Loaiza played for numerous teams between 1995 and 2008, starting with the Pittsburgh Pirates and concluding with his second stint with the Chicago White Sox.
The 46-year-old is the second-winningest pitcher from Mexico in Major League Baseball history, trailing only Fernando Valenzuela's 173 wins.
According to Baseball Reference, Loaiza made more than $43 million over a career that spanned parts of 13 seasons, and he was a two-time All Star.
Karkenny requested that the court hold a hearing to make sure that any money Loaiza might use to post bail didn't come from illegal activity. It was not immediately known if Loaiza had hired a lawyer and the former player could not be reached to comment.
"I love Esteban", Boggs told the San Diego Union-Tribune. The "Diva de la Banda" was considered to be the most successful female singer in grupero, a male-dominated Mexico regional style, selling more than 15 million records, and acting in reality television before she was killed in a plane crash in 2012. "He's a great guy with a big heart - again, I don't know what or why he'd be involved in this". He later retracted his lawsuit.