Earlier, Amit Panghal won silver medal after losing to England's Galal Yafai in men's 46-49kg final.
Manika put up a dominating show against Singapore's Mengyu Yu to sweep the gold medal 4-0 (11-7, 11-6, 11-2, 11-7), adding to her yellow metal from the women's Team event at Gold Coast.
Manika seemed to be India's biggest surprise in Gold Coast as she kicked off her way into the third table tennis finale on Saturday sunrise.
Just like the Team event, Manika troubled Yu with a lot of heavy top spin and inconsistent back spin.
Manika is only the second player from India after Sharath Kamal to win a singles medal in table tennis at the Commonwealth Games.
India has so far won 24 gold medals at the CWG 2018. The doubles pair of Ashwini Ponnappa and Sikki Reddy won the bronze medal match against Australian pair 21-19, 21-19.
Bronze for men's doubles Harmeet Desai and Sanil Shetty bagged the bronze medal in the men's doubles category. In badminton, Kidambi Srikanth, Saina Nehwal have made it to the finals. Tianwei and Mengyu came well prepared to counter Batra's variations with the pimpled rubber and cruised to a 11-5, 11-4, 11-5 victory. The Indians lost 0-2 (8-11, 10-11) to home favourites Donna Urquhart and Cameron Pilley in 29 minutes.
Joshna Chinappa and Dipika Pallikal beat England's Laura Massaro and Sarah-Jane Perry 11-10, 11-5 to enter women's doubles squash final.