The players had just ventured down the tunnel and into their respective dressing rooms for half-time when the referee, Guido Winkmann, suddenly ordered them all back out onto the pitch.
Mainz moved above free-falling Freiburg in the table and up to 15th, ending their own six-game winless run in the process.
In the dying seconds of the first half, Mainz had an appeal for handball turned down by referee Guido Winkmann, with the scores still at 0-0.
The curse of VAR struck again as chaos descended during Mainz's game against Freiburg in the Bundesliga.
De Blasis added a second with ten minutes remaining, but there is likely to be significant fallout from this match (and that decision in particular) in the coming days.
And so, after a lengthy delay, the players returned and Pablo de Blasis opened the scoring for the hosts.
Protests also delayed the initial kickoff, and the whole game took place to the sound of shrill whistles as supporters made their displeasure known with the German football league.
It was so loud that Mainz coach Sandro Schwarz even said afterwards that it was distracting, while VAR project leader Lutz Michael Fröhlich even suggested the noise had hampered the referee's ability to hear the video assistant on the crucial penalty call.
The confusion continued after the break, as fans threw toilet rolls onto the pitch in protest against Monday night games, delaying the restart by several minutes.