Russian Ambassador to the UN Vasily Nebenzya said the attack was an act of aggression against a sovereign state and that the U.S. and its allies have demonstrated a blatant disregard for worldwide law.
Guterres urged the Security Council to "act responsibly in these risky circumstances", according to AFP.
U.N. Secretary-General Antonio Guterres has warned against any further escalation after the U.S., U.K., and France jointly launched airstrikes targeting the Assad regime's alleged chemical weapons capabilities in Syria.
The Security Council has primary responsibility for the maintenance of worldwide peace and security.
"I have repeatedly expressed my deep disappointment that the Security Council failed to agree on a dedicated mechanism for effective accountability for the use of chemical weapons in Syria", his statement said. I call on the members of the Security Council to unite and exercise that responsibility.
"We extend our heartfelt prayers to the people of Syria whom have suffered long enough, and continues to be deeply affected, by the conflict and cross-fires between both sides of the divide", he said.
Syria has firmly denied any links to the attack, which reportedly killed at least 60 people and wounded more than 1,000 others.
Two groups of experts from the Organisation for the Prohibition of Chemical Weapons (OPCW) will arrive in Syria on Thursday and Friday, Syria's Ambassador Bashar Jaafari said.
His plea comes after the mandate of the Joint Investigative Mechanism (JIM), which was created as a body to attribute responsibility for the use of chemical weapons in Syria in 2015, expired in November 2017. Russian Federation says the number of casualties is not true.
US President Donald Trump has Tweeted that Russian Federation should "get ready" for the firing of missiles at Syria as Washington continues to assert that the Syrian government was behind an alleged chemical attack east of Damascus on Saturday.
Russia's foreign minister has asserted that a suspected chemical attack in the Syrian town of Douma last weekend was fabricated with the help of an unspecified foreign intelligence agency.
Asked whether Washington has proof Assad launched the attack on Douma, the main city in the former rebel bastion of Eastern Ghouta, State Department spokeswoman Heather Nauert said: "Yes".