The small, private aircraft was located in a field, according to the Virginia State Police.
Responding officers are working to confirm what kind plane it is, reporting it as "unrecognizable" after being engulfed in flames.
The flight was heading for DeLand, Florida, according to WBNS in Columbus, DeLand sits on the east coast of the state, west of Daytona and North of Orlando.
The crash happened around 9 p.m. on Saddle Hollow Road near Crozet.
Officials didn't immediately share the identities of the people who died.
The remains of the victim will be transferred to the Office of the Medical Examiner for autopsy, examination and positive identification.
The cause of the crash was unknown.
The Federal Aviation Administration said the Beechcraft Bonanza went down Monday morning in a wooded area of Coshocton County, roughly 60 miles northeast of Columbus.
This is a developing story.