Pro-Syrian regime outlets and social media accounts reported that air defences had foiled a missile attack on Shayrat airbase near Homs, the same location that was targeted in USA missile strikes past year.
The U.S., Britain and France targeted military and research sites in Syria after the purported toxic attack on Eastern Ghouta's last moderate opposition holdout of Douma a week earlier.
Following reports of an Israeli strike, an Israeli military spokesman said: "I'm not aware of such an incident".
Asked about the missile attack, an Israeli military spokesman said: "We don't comment on such reports".
Big explosions were heard on Monday night near the same air base, southeast of the city of Homs, and in eastern Qalamoun near Damascus where two other air bases are located, the Syrian Observatory for Human rights reported.
Macron met earlier with representatives of the aid groups who spelled out the humanitarian needs of a population that has endured seven years of war. Those attacks were retaliation for a suspected chemical weapons attack that they blamed on the Syrian government.
The U.S., along with the United Kingdom and France, conducted airstrikes on Saturday in Syria to punish the Assad regime for an apparent chemical weapons attack against civilians.
Israel has previously carried out air strikes during the conflict in Syria, targeting Iran-backed militias fighting alongside the forces of Syrian President Bashar al-Assad.