The previous five seasons all contained 22 episodes.
Past year at this time, the series from showrunners Jed Whedon and Maurissa Tancharoen negotiated a reduced licensing fee that helped secure a fifth-season pickup as ABC used the drama to establish a night of genre programming on Friday.
The Season 5 finale will air Friday, May 18 at 9/8c on ABC.
Marvel's Agents of S.H.I.E.L.D. follows an elite group of agents who investigate odd occurrences. It hasn't yet been determined if Season 6 will be the show's last, but no doubt the showrunners would like to know beforehand if they're crafting an endgame or if there's hope for the show to continue on past Season 6 with shorter seasons.
Marvel's Agents of S.H.I.E.L.D. now airs Friday nights at 9/8C. Though it can be a bummer for fans, it's not much of a surprise to see the series get shuffled around the schedule to a less competitive period. That said, Season 6 will nearly certainly have to acknowledge the fact that Show Spoiler half of the known universe has vanished with the snap of Thanos' finger. Or pick up after Avengers 4? It's all just theories for now, but never forget #itsallconnected.
Cast announcements for season 6 aren't expected until a later date, but we can at least take solace in the fact that Clark Gregg's super agent will be returning in time for 2019's Captain Marvel movie, given its 90s setting.