The final set alone lasted for two hours and 50 minutes. Not only is he advancing to the first Grand Slam semifinal of his career at Wimbledon, he and his wife, Highland Park native Madison McKinley, are expecting their first baby girl.
And when asked about his upcoming semi-final, Isner said: "It's a huge match, for sure".
He finally broke the 33-year-old American in the 49th game of the decider after coming close in a couple of earlier games and looked impassive as he held his nerve to secure victory.
This put the 32-year-old Anderson in a good spot as Federer was not playing on his favourite Centre Court.
On Friday, the American became embroiled in another marathon contest, he and fellow big-server Anderson - who sensationally beat defending champion Roger Federer 13-11 in a fifth set on Wednesday - trading ace after ace in search of a place in the final at the All England Club.
Isner did, however, break the record of the most serves at a tournament - beating Goran Ivanisevic's 213 on his way to the Wimbledon back in 2001.
Anderson and Isner's main strength is their service game, which was pretty apparent given that three sets went to a tie-break.
Raonic delivered what was expected of him, smashing 31 aces to Isner's 25 in a booming encounter, but a failure to convert a set point in the second set tiebreak proved crucial.
That inconsistency was eliminated in an absorbing final set before Anderson produced a moment of magic.
On the most crucial point of the match, Anderson recovered after a fall and hit a lefty forehand to go up 0-30 while Isner was serving at 24-24. Djokovic owns 12 Slam trophies, three from Wimbledon.