Almost 2.3 million STDs were diagnosed previous year, which is a record number.
It marks the fourth consecutive year of sharp increases in STDs, the CDC said.
The data, which was presented at the 2018 STD Prevention Conference, found a 67 percent increase in gonorrhea diagnoses, which officials sounded alarm over due to the growing threat of untreatable strains.
Primary and secondary syphilis diagnoses increased 76 percent between 2013 and 2017.
Increases in gonorrhea among women "are also concerning", said the CDC report, with cases going from 197,499 to 232,587 in a single year from 2016-2017.
"We are sliding backward", said Jonathan Mermin, M.D., M.P.H, director of CDC's National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. More than 1.7 million cases were diagnosed in 2017, with 45 percent among 15- to 24-year-old females.
Newer drugs that made HIV less lethal and infectious may have contributed to declining condom use - and the increase in STDs in America, Dr. Gail Bolan, head of the CDC's Division of STD Prevention, told NBC News.
Gonorrhoea infections also surged by 18%, while chlamydia case were up 6% within the last 12 months. Only one antibiotic available in the United States, ceftriaxone, is highly effective in treating gonorrhea.