Tiredness could be an issue for Son, who played eight games in 26 days for his country, but his return after playing just ten minutes of Tottenham's league season so far will be greatly received by Spurs boss Mauricio Pochettino.
Tottenham have fined their goalkeeper two weeks' wages - about £240,000 - on top of the £50,000 fine and 20-month driving ban handed down by a court after he pleaded guilty yesterday.
Hugo Lloris on the other hand, is not injured, but was pulled over by police for driving while intoxicated about which the Argentinian coach stated: "He said he is sorry, anyone can make a mistake, he did it and he is suffering, he is punishing himself".
"He said "Gaffer it's a massive lesson for me".
Pochettino, though, says he knows Kane better than anyone.
"Only we need to try, that he understands, and how he understands that it was a mistake".
Goalkeeper Lloris sustained a thigh problem during last month's 3-0 win at Manchester United, which meant he missed the subsequent 2-1 loss at Watford and France's global commitments over the past week.
To accompany his captain's drink driving, Tottenham's financial commitment to building their new stadium culminating in the manager being unable to buy a single player in the transfer market and the club's proposed move-in date to the new White Hart Lane remains uncertain, with a Carabao Cup fixture against Watford now having to be played at MK Dons' ground.
'And of course it's more complicated today to be a manager than 20 or 30 years ago'.
"We are disappointed because we are going to miss him for this game and maybe against Inter in the Champions League. I did. Rather than congratulate him, people need to thank me".