She was voted the newcomer of the year in 2016, she was not ranked 100 or so at the start of the year, but at number 68; she was seeded 20 at the US Open, Serena was seeded 17; and she showed that she was a contender and a serious challenger going into the tournament.
Although her coach admitted to coaching during the game in an interview with ESPN, he also called for change, although his message might have been drowned out at the time.
But much of the ensuing outrage chose to ignore Williams' claims of unfair treatment.
Matters escalated and Williams called Ramos a "thief", incurring the crucial game penalty. Ramos didn't reply to the outbursts.
One of the most controversial Grand Slam finals of all time divided tennis and triggered a debate about sexism in the sport, fuelled by Williams's assertion that Ramos would not have dealt with a male player in the same way.
Those double standards and discrimination is something Williams has experienced her entire career, despite possibly being the best tennis player to ever play the game.
The US Open was Osaka's biggest title to date after winning in Indian Wells in March earlier in the year. He said so after the match (although Williams was adamant they don't have any established signals).
The 36-year-old then began ranting at umpire Carols Ramos and stormed over to his chair shouting: "I don't cheat to win!"
Naomi Osaka holding her trophy after winning the women's singles finals tennis match at the 2018 US Open.
Miss Williams has caused quite the furore over claims of sexism in tennis, and while I don't think this incident demonstrates it, I have to ask myself if my indifference, even disagreement with her stance makes my attitude in itself sexist. She's been booed. She's been called the N-word. The umpire counted that as the second offence and denied her a point.
Serena, in fact, has been the target of racist messaging that she isn't welcome in the sport she dominates.
The CEO of the Women's Tennis Association, Steve Simon, also issued a statement backing Williams on Sunday and said that his organization "believes that there should be no difference in the standards of tolerance provided to the emotions expressed by men vs. women", while also adding they he did "not believe that this was done last night". She didn't threaten, and she didn't curse.
"I saw how Serena was being treated, and then I thought about coming back to my locker one day as a player, and there was [a reporter] in my chair", said Aaron, who endured racist taunts and death threats as he marched toward Babe Ruth's record. However, as soon as a player questions an umpire's integrity they are gone.