Victory over Guardiola's side would cut the gap at the top to six points but Mourinho refused to say the derby is a chance for his team to get back into the title race.
It was ideal preparation for Sunday's trip to Pep Guardiola's City, where another tough 90 minutes lies in wait for Lindelof and his team-mates.
In the aftermath of the game, Ronaldo again drew more derision from some Old Trafford faithful when he blatantly said Jose Mourinho's side didn't deserve the win.
"It's a very important match for two reasons. because it's the Manchester derby and also because if we win we will put distance between ourselves and them in the table". Yet they have also fallen into the habit of going behind in matches. "If you want to speak about their football potential, we can speak and football potential starts with investment".
Allegations of financial impropriety off the field couldn't derail Manchester City moving to the brink of the Champions League last 16 as Gabriel Jesus scored a hat-trick in a 6-0 thrashing of Shakhtar Donetsk on Wednesday.
"We are always ready to compete and need to take advantage of the good momentum of the team at the moment".
The 25-year-old's relationship with his Red Devils manager has been in shambles few months after winning the Europa League in 2017.
The 24-year-old had some hard moments during his maiden campaign but has kicked on this term and started all five matches since the last global break.
Although the Red Devils eventually won the game 2-1, with Juan Mata and an Alex Sandro own goal overturning the result, many United fans have been left divided over the Portuguese's action during the game.
"At the moment I feel good - my body is fresh".