After joking about a report suggesting he would be named godfather to Harry and Meghan's baby, Clooney said: 'They're just chasing Meghan Markle everywhere, she's been pursued and vilified. She died in a auto accident in 1997 after the driver of her vehicle attempted to shake off pursuing photographers.
Meghan Markle has poured her heart out in a letter to her father, Thomas Markle, telling him he has broken her heart, accusing him of lying to the press and asking him to let her and husband Prince Harry "live our lives in peace".
"We've seen how that ends", Clooney continued. She had been under intense media scrutiny for several years after the breakdown of her marriage to Prince Charles.
Clooney told reporters at a Television Critics Association conference in Pasadena, California that Meghan is "a woman who is seven months pregnant and she has been pursued and vilified and chased in the same way that Diana was and it's history repeating itself".
Kensington Palace has not yet responded to CNN's request for comment.
According to Ms Nicholl, Harry "had suspected his brother would come back engaged" after William whisked Kate off on a romantic three-week holiday to Kenya.
Meghan also accuses her father of snubbing her and Prince Harry's offers to help when he pulled out of attending their wedding following two heart attacks and accuses him of being ungrateful for money she has given him.
Tabloid newspapers have frequently carried alleged details of her family relationships, and several have also reported on a supposed rift between her and Catherine, the Duchess of Cambridge, in recent months. She wrote: "You fixated and clicked on the lies they were writing about me, especially those manufactured by your other daughter, who I barely know. I'm sort of surprised by that".
Meghan laughed as a relative of one of the children showed her a photo on her phone, zooming in on the image to get a closer look.