Like in the quarter-finals, the second leg will be played in the following week on Tuesday 7 or Wednesday 8 May, between our weekend league games against Huddersfield Town and Cardiff City.
The first leg will take place at Spurs' new stadium on April 9, with the return leg at the Etihad Stadium on April 17, before a Premier League clash between the pair in Manchester just three days later.
The victor of that tie will host either Ajax or Juventus in the first leg of the semi-finals.
Followed closely behind City is none other than Premier League-challenging rivals Liverpool, with the Reds holding an impressive 93.1 SPI rating.
'We're at home on Sunday and the way we've played under me, Chelsea was front foot and aggressive and Leicester second half was one I want the team to be like.
Man United or Barcelona vs.
Manchester United's tie against Barcelona means caretaker manager Ole Gunnar Solskjaer will enjoy another trip to the Nou Camp, where he scored the victor in United's Champions League final win over Bayern Munich in 1999.
English hopes are high that this could be their year in Europe's elite club competition after all four of their representatives made it through to the last eight.
Ajax last won the Champions League in 1995, while Manchester United last won in 2008 and Juventus most recently won in 1996.
The Reds have won each of the last five meetings with the Cottagers across all competitions - a new club record run versus the London side.
The last time the Premier League had four teams in the quarter-finals, in 2008/09, Barcelona beat the Old Trafford side 2-0 in the final in Rome.
Having done away with German giants Bayern Munich, Liverpool were arguably handed the easiest assignment as they were drawn alongside Porto while Cristiano Ronaldo's Juventus will take on Real Madrid conquerer's, Ajax.
The Red Devils, however, might just find some solace in Messi's awful record in Champions League quarter-finals.