Emergency crews rushed her to St. Barnabas Hospital where she later died.
Her uncle Gregory Monfries, said: "This is not a good time".
Together with fellow students climbed the Sydney m.in the night from Saturday to Sunday, the granite tower on the Campus of Fordham University in the Bronx.
'She couldn't breath. She hit her head, ' he said.
Though the trek to the top of the locked tower is forbidden, it's become a rite of passage for outgoing students who sneak into the off-limits property at night, according to the school's newspaper, The Fordham Ram.
Gina Vergel, a university spokeswoman, told The Post that the door to the clock tower is always locked and that only facilities and public safety staff should be able to access it.
According to USA media reports, Ms Monfries slipped on her way up the tower's spiral staircase and was found by emergency services at about 3.17am.
Sydney Paige Monfries, a 22-year-old woman from Portland, Oregon, has been identified as the Fordham University student who tragically passed away on Sunday, April 14, following a fall from a campus clock tower.
Monfries was an intern at InStyle magazine.
"It is with great sadness that I report that Sydney Monfries, a senior at Fordham College at Rose Hill, died today after sustaining a fall inside the Keating Clock tower in the early hours of the morning", university president Joseph McShane wrote in a letter to students, according to the New York Post.
The Sun reported another student, only identified by the first name Dave, claimed Ms Monfries and her friends had dined at a restaurant where he worked shortly before the accident. The group had sent a Snapchat video from the top of the tower. You were so smart, pretty and kind just like your momma.
Shristina Harrigan added: 'Rest in sweetest peace Sydney. "I, personally, never heard about that". Rest easy sweet girl'.
Monfries was described as the "sweetest soul" by her friends.