During a closed door meeting on Capitol Hill last Tuesday, Pelosi told key Democratic committee leaders "I want to see him in prison" rather see Trump be impeached, according to officials familiar with the conversation.
"I'm done with him", she said Tuesday at an event hosted by the Peter G. Peterson Foundation.
Trump lashed out at her in response to that comment during a Fox News interview from the Normandy American Cemetery in France, calling her "a nasty, vindictive, awful person".
"This [statement] borders on so totally unethical, he doesn't even realize it", she told reporters.
Pelosi has so far resisted starting an impeachment inquiry, even as a growing number of House Democrats have said publicly they are in favour of starting one.
"I just consider the source. I'm not going to talk about him anymore".
"If we didn't have a Constitution and these Democrats who run these committees were in charge, it'd be like the French committees during the French Revolution, where they'd be declaring people guilty with a guillotine next to them and lopping their heads off".
Pelosi repeated her previously expressed view that impeachment of Trump is "not off the table", but stopped short of saying whether she has an obligation to mount an impeachment inquiry. "We have plenty of time to do that when we're back home", she said.
Pelosi made the remark at a news conference on Thursday.
"I don't care what motivates him, and we never know", Pelosi said when asked about her alleged comments. But at the rate he's been flip-flopping, don't bet he'll hold out for long.
She said that even on the question of rebuilding US infrastructure, which Trump had often said he wanted to do, "when it came to pay for it, he diverted attention to personal matters".
The interview took place on the 75th anniversary of D-Day while Trump was at the Normandy American Cemetery in France.