The Tour de France is only three and a half weeks away and Froome's preparations this season have been built around peaking for the race as he aims to join an elite group of just four riders to have won five Tour titles.
A message posted to Froome's official Twitter account Wednesday afternoon, apparently by his wife Michelle, said the cyclist was in surgery to fix "multiple fractures".
Britain's four-times victor of the Yellow Jersey was airlifted to hospital with multiple injuries - including a broken leg, broken elbow and fractured ribs - after a crash that shook cycling.
Team INEOS leader Dave Brailsford said Froome sustained a suspected fractured femur in a 60 km/h crash.
Four-time Tour de France champion Chris Froome has suffered a major crash resulting in multiple fractures and will miss this year's race.
"They were going very fast and the wind got his front wheel and sent him straight into the wall", Brailsford said in French. We're trying to manage that and make sure he gets the best care. "He is now being airlifted to St Etienne University Hospital for further treatment", Team INEOS doctor Richard Usher said in the statement.
"One of our big strengths on this team is coming together in hard moments, and we will ensure we do everything possible to support Chris and his family".
Froome's crash came towards the end of his recon of Wednesday's time trial course, a stage that was expected to see him challenge for the overall lead of the Dauphine.
The 34-year-old was using the race as part of his build-up to this year's Tour de France, which starts on July 6.
Froome's injuries, which will nearly certainly rule him out of the world championships in Yorkshire in September, stunned Tour de France organisers.