Cherry-Evans has been an outstanding leader in his first series as captain and his heartbreak in the Queensland sheds was palpable.
Tedesco fittingly scored the match victor in the dying seconds to cap a stunning two-try display that earned him the Wally Lewis Medal as player of the series.
"If he doesn't throw the ball out there and he doesn't spot the space, we're going into extra time", NSW coach Brad Fittler said.
Pearce finally got his flawless Origin moment after throwing the long-range cut-out ball that allowed Blake Ferguson to sprint down the touch line before passing back inside to Tedesco. "It was pretty special to win the series past year but, to win it again, is magic".
RESULT: NSW 26 (James Tedesco 2, Paul Vaughan, Damien Cook tries; James Maloney 4 conversions, 1 pen goal) defeated Queensland 20 (Felise Kaufusi, Josh McGuire, Josh Papalii tries; Ethan Lowe 3 conversions 1 pen goal).
When Lowe's conversion sailed through, Origin was seemingly set for a golden point contest in front of a sellout 82,565 crowd at ANZ Stadium.
Tedesco produced a series of huge plays in both halves of football.
Tedesco's individual brilliance was the only thing that separated the two sides in the end - further pushing the case for his 2019 series to be remembered as one of the greatest individual series ever produced in State of Origin.
In one of the most dramatic finishes in Origin history, scores were locked at 20-all in the final minute on Wednesday when Mitchell Pearce had the ball in his hands.
I could never see the player he is today at all.
Former Queensland player Brent Tate has come out in support of coach Kevin Walters, urging the Maroons hierarchy to stick with him as head coach next year despite two consecutive series losses.
"I thought Papalli was our best player last night, I thought he was outstanding, and with our attack Munster was risky every time we got the ball". He just ran out of time.
"It's not all just about running, I understand playing my role a bit more now and trying to bring a few things into my game this year so I definitely feel like I'm growing as a player".
"I guess when you go for a field goal at that stage and you miss, you give up seven tackles and (give) the opposition a chance to get down your end and do something themselves".
"No, I'm a really proud Queenslander tonight".
"Every single person that wears this Queensland jersey is proud to put it on and I'm the lucky guy that gets to lead them out".
It was just the beginning of the headaches for the Maroons.