Federer is the first player to win 100 matches at one Grand Slam tournament.
The duo have not met at the All England Club since their titanic tussle in the 2008 final, when Nadal outlasted Federer over five thrilling sets that finished late in the evening gloom.
Federer had already beaten Jimmy Connors' US Open record of 98 wins at a Grand Slam championship with his victory over Matteo Berrettini.
"I know they haven't played here in a long time".
Roger Federer won his 100th match at Wimbledon by beating Kei Nishikori in the quarter-final on Wednesday. Federer's transition from back court to front court is better than Nadal's and I see that being the reason for the Swiss master having more success at Wimbledon. Again serving for that set at 6-5, he erased a trio of break points for Querrey before holding - and finally was on his way.
"Difficult to imagine to be again in that situation and here we are". These are, after all, two of the greatest players in history, winners of more Grand Slam titles than any other men who have played tennis.
"I knew I had a good opportunity to play in the semi-final and I did very well". Actually not at all, not once.
"To have three months off, come back, make a final and a quarterfinal, I feel confident", Querrey said.
He went on to discuss the prospect of facing Djokovic for a ticket to the final.
Djokovic had an easier time against David Goffin after erasing an early break, winning 6-4, 6-0, 6-2. Djokovic fended off two break points in the third game before getting broken in game seven after a well-constructed attack from David who was the better player in the first 35 minutes. "That's certainly going to give him confidence coming into the match", Djokovic said.
"The fan told me, "Congratulations, Roger, on your 100th", Federer said. "Hopefully I can win a handful of matches (in the U.S.) and keep my ranking going in the right direction".
"I really can not be happier".
Djokovic is 5-1 against Goffin, but he lost to the Belgian on clay in Monte Carlo in 2017. It´s so tough. Even if you play well, it´s not enough because he continues to play deep, close from the line, left, right.
"He was everywhere, " Goffin said.
Bautista Agut, 31, booked his first appearance in a Slam last-four at the 27th attempt by seeing off Pella, who had never previously reached a quarter-final at the majors. "My friends, six of them, are all there", Bautista Agut said. I guess this is where - especially Nadal, Federer and myself, in a way - we go onto the next level in terms of tennis and focus.