Missing a mid-week practice normally doesn't bode well for a player suiting up the following weekend.
The team has lost two straight games and is playing their divisional rivals, the San Francisco 49ers who just so happen to be undefeated.
McVay said it is "hard to say" if Gurley will be ready for Sunday's game against the 49ers.
Gurley, 25, was limited throughout the offseason with a leg injury. The running back is averaging career-lows in carries per game (12.8), rush yards per game (54), touches per game (15.6), and scrimmage yards per game (67.6).
If Gurley is unable to play, expect Malcolm Brown and rookie Darrell Henderson to carry the load at running back for the Rams. During the NFC Championship Game and the Super Bowl, Gurley was practically nowhere to be found and reports started to circulate that he had arthritis in his knee. In addition to Gurley's uncertain status, the Rams also ruled out cornerback Aqib Talib. Matthews suffered his injury in last Thursday's loss in Seattle and is expected to miss about four weeks.